The patch has altered the game files and anti-cheat mechanisms so much that some AV and Firewall wall systems were stopping PS2 from running.
Comodo and Avast are both detecting nasty behavior and preventing the game from running.
Comodo needs all the defense+ stuff to be disabled permanently.
Avast you need to shut it down completely (wait a few minutes) and then PS2 should run fine.
Not Ideal, but there you go.
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